Priority 01
GPR6 in depression
We are investigating GPR6, a receptor on dopamine-signalling neurons, as a novel therapeutic target in depression — using the GPR6-targeting drug CVN424 to probe striatal circuits and behaviour.
◆Translational Neuroimaging — Aarhus University
Imaging the living brain.
We use molecular brain imaging to find new therapeutic targets and biomarkers for psychiatric and neurodegenerative disease — tracking how brain circuits respond to disease and therapy, from rodents to large animals.
FOV 240 mm
● ACQUIRING
RECON · ITER 128
PET · MRI
01 — Research
Three priorities, one molecular-imaging toolkit.
We pair PET tracers with MRI, disease models, behaviour, and tissue analysis to connect specific brain targets to function — and to move discoveries toward the clinic.
Priority 02
Synaptic PET with SV2A
We use SV2A / [¹¹C]UCB-J PET to image synaptic change in disease models and in response to therapies — including deep brain stimulation, exercise, and S-ketamine.
Priority 03
Neuroinflammation biomarkers
We are developing imaging biomarkers of neuroinflammation across neurodegenerative and psychiatric disease — turning the brain's immune response into a measurable read-out.
Methods
Multi-tracer molecular PET
Beyond SV2A: dopamine synthesis (FDOPA), metabolism (FDG), and receptor autoradiography.
Methods
Translational models
Rodent, large-animal (Göttingen minipig), and transgenic mouse models of brain disease.
Methods
Multimodal & longitudinal
Pairing PET with in vivo and ex vivo MRI (microstructure, diffusion), behaviour, and tissue.
Reconstructing signal from measurement — schematic
The lab
From molecules and circuits to the clinic.
The Landau Lab develops and validates molecular brain imaging to track how neural circuits adapt across disease, injury, and therapy. Working across rodent, large-animal, and genetic models, we combine PET with MRI, behaviour, and tissue analysis.
Our aim is consistent and translational: read-outs that can move from the bench toward the clinic.
Part of the Translational Neuropsychiatry Unit ·
Department of Clinical Medicine, Aarhus University
Department of Clinical Medicine, Aarhus University
02 — People
Led by Anne M. Landau.
AL
Anne M. Landau
Associate Professor · Principal Investigator
GroupTranslational Neuroimaging
UnitTranslational Neuropsychiatry Unit
Dept.Clinical Medicine, Aarhus University
Profiletnu.au.dk ↗
Join the lab
Curious, rigorous people welcome.
We host project students, PhDs, and postdocs who want to work at the interface of imaging, neuroscience, and translation. If our work resonates, we'd love to hear from you.
Get in touch →03 — Publications
Selected work.
A selection of recent peer-reviewed publications from the group and its collaborations.
For the full, up-to-date publication list, see Anne M. Landau's profile at Aarhus University ↗.